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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Protection of neurons against oxidative stress is crucial during neuronal development, maintenance and for treating neurodegenerative diseases. However, little is known about the molecular mechanisms underlying sex-specific maturation and survival of neurons.
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NF-κB p65 directs sex-specific neuroprotection in human neurons.

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International NF Collaborative Research Reveals Brain Sex Differences | Gutmann Research Laboratory

One of the major goals of my research is to delineate the molecular mechanisms behind sexual dimorphism in neonatal mortality and morbidity. In the long-term, our research is aimed at improving lung health in premature babies and identifying new therapeutic targets. Bronchopulmonary dysplasia BPD is a debilitating lung disease with long-term consequences and is one of the most common causes for morbidity in premature neonates. Postnatal exposure to high concentrations of oxygen hyperoxia contributes to the development of BPD. Male sex is considered an independent predictor for the development of BPD.
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NF-κB p65 directs sex-specific neuroprotection in human neurons

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